September 30, 2001

Tom Brady makes the first start of his NFL career, and he leads the Patriots to a 44-13 win. Brady didn't throw a touchdown, but he didn't throw an interception, either. Manning was picked off three times. Brady is heard saying, "This starting stuff is easy."

October 21, 2001 -

Tom Brady shows a little more in the rematch against Manning, as he tossed three touchdown passes in a 38-17 win. The Patriots would go on to win the Super Bowl.

November 30, 2003 --

Peyton Manning throws four touchdown passes against the Patriots, but Tom Brady's fourth-quarter score to Deion Branch was the difference in the Patriots' 38-34 victory.

January 18, 2004 --

Peyton Manning throws four interceptions in the 2003 AFC Championship Game as the Patriots move on to win their second Super Bowl.

September 9, 2004 --

The Patriots open the 2004 season with another victory over Peyton Manning and the Colts. Good news, Peyton only throws one interception in this game. That's progress.

November 7, 2005 --

The football world is stunned when Peyton Manning throws three touchdown passes as the Colts destroy the Patriots, 40-21. Many wait around for the handshake to see if Ashton Kutcher emerges to tell everybody they've been Punk'd. He doesn't, and Peyton ends a six-game losing streak to Tom Brady.

January 16, 2005 --

The Patriots hold Peyton Manning and the Colts to just three points in this divisional round playoff game. It looks like Tom Brady just told Peyton a joke about the bear and the hunter in the woods.

November 5, 2006 --

Peyton Manning makes it two consecutive wins over Tom Brady, as it's the Patriots' quarterback who throws four interceptions in the loss. Many football enthusiasts wonder if the plot of "Face Off" is real and the quarterbacks have been switched.

November 4, 2007 --

Tom Brady has to rally the Patriots this time with two fourth-quarter touchdown passes to Wes Welker and Kevin Faulk as New England improves to 9-0 with a 24-20 victory. Suddenly, things seem right again in the football world.

January 21, 2007 --

In something nobody saw coming, Peyton Manning actually rallies the Colts for a clutch victory in the AFC Championship Game. If you look at the photo, Tom Brady has the same look on his face as an older brother does when his mother tells him to let the little brother win. Manning would go on to win the Super Bowl in the most unlikely title victory since David Arquette won the WCW heavyweight title.

November 15, 2009 --

In one of the most bizarre endings to a football game, Patriots coach Bill Belichick goes for it on fourth-and-short deep in his own territory late in the fourth quarter. The move backfires and Peyton Manning wins it with a 1-yard touchdown pass to Reggie Wayne. Tom Brady is seen here saying, "Yeah, I don't know what he was thinking, either." (Actually, it was the right move by Belichick.)

November 21, 2010 --

Tom Brady wins the final installment of this rivalry (and presumably the last one as Patriots and Colts, respectively) with a win, 31-28. Peyton Manning valiantly tries to rally his team late in the game, but they are done in by his three interceptions. Manning done in by interceptions? Hard to believe, but it's true.

October 7. 2012 - He was in a different uniform, but Peyton Manning, now a member of the Denver Broncos, went through a familiar result. Tom Brady and the Patriots won 31-21 in Foxborough. Brady threw for 223 yards and one touchdown.

November 24, 2013 - In their 14th epic battle, Tom Brady and the Patriots fell behind 24-0 at halftime to Peyton Manning and the Broncos. However, Brady waged a comeback and led the Patriots to a come-from-behind victory in overtime to defeat the Broncos 34-31. Brady is now 10-4 lifetime against Manning.

January 19, 2014 - Tom Brady and Peyton Manning met for the 15th time in the AFC Championship. The Broncos earned a trip to Super Bowl XLVIII, defeating the Patriots 26-16.

November 2, 2014 - Tom Brady outdueled Peyton Manning, throwing for four touchdowns, and Julian Edelman returned a punt 84 yards for a score in leading the New England Patriots past the Denver Broncos 43-21.