Details: Friday, 9 p.m. ET, ESPN2
What's at stake? In back-to-back weeks, the Utes get a chance to knock off a Big Ten team (Michigan) and an in-state rival, while Utes star RB Devontae Booker looks to rebound from a sluggish opener.
Matchup to watch: Utah State QB Chuckie Keeton vs. Utah LB Jared Norris.
Game picks:
Brandt: Utah, 28-24
Brooks: Utah, 22-20
Davis: Utah, 42-28
Goodbread: Utah, 31-17
Jeremiah: Utah, 34-21
Reuter: Utah, 38-17
Zierlein: Utah, 27-17

Details: Saturday, 7:30 p.m. ET, SEC Network
What's at stake? It's a huge opportunity for Wildcats QB Patrick Towles, who is the most talented passer UK has had since Jared Lorenzen, to show he can be one of the SEC's best.
Matchup to watch: Kentucky QB Towles vs. South Carolina LB Skai Moore.
Game picks:
Brandt: South Carolina, 31-24
Brooks: South Carolina, 24-20
Davis: South Carolina, 24-23
Goodbread: Kentucky, 24-21
Jeremiah: Kentucky, 21-20
Reuter: South Carolina, 28-24
Zierlein: South Carolina, 34-28

Details: Saturday, Noon ET, ESPN3
What's at stake? The Louisville quarterback job is in flux, and this game could help decide it for the season. Exciting freshman Lamar Jackson makes his first career start vs. Houston after coming off the bench to give the UL offense late life against Auburn last week.
Matchup to watch: Houston CB William Jackson vs. Louisville WR James Quick.
Game picks:
Brandt: Louisville, 35-20
Brooks: Louisville, 38-37
Davis: Louisville, 45-35
Goodbread: Louisville, 35-10
Jeremiah: Louisville, 59-24
Reuter: Louisville, 45-31
Zierlein: Louisville, 34-28

Details: Saturday, 3:30 p.m. ET, CBS Sports Network
What's at stake? The Golden Gophers will have the full support of Buckeye Nation for this one. Why? Ohio State's weak schedule will only look weaker if Minnesota loses to a non-Power Five program.
Matchup to watch: Minnesota DB Briean Boddy-Calhoun vs. Colorado State WR Rashard Higgins.
Game picks:
Brandt: Minnesota, 28-21
Brooks: Minnesota, 25-21
Davis: Colorado State, 30-28
Goodbread: Minnesota, 28-21
Jeremiah: Minnesota, 21-18
Reuter: Colorado State, 28-24
Zierlein: Minnesota, 30-14

Details: Saturday, 3:30 p.m. ET, ABC
What's at stake? The Fighting Irish are a legitimate College Football Playoff contender, but with tougher games ahead, including battles against Georgia Tech, Clemson and USC, it can't afford a loss here.
Matchup to watch: Notre Dame QB Malik Zaire vs. Virginia DB Quin Blanding.
Game picks:
Brandt: Notre Dame, 27-17
Brooks: Notre Dame, 28-17
Davis: Notre Dame, 50-14
Goodbread: Notre Dame, 38-17
Jeremiah: Notre Dame, 38-14
Reuter: Notre Dame, 35-14
Zierlein: Notre Dame, 27-24

Details: Saturday, Noon ET, ABC
What's at stake? Losing to a solid Utah team on the road in his debut didn't take any shine off of new coach Jim Harbaugh for the Wolverines. Losing to the Beavers at home would.
Matchup to watch: Oregon State WR Jordan Villamin vs. Michigan DB Jabrill Peppers.
Game picks:
Brandt: Michigan, 34-13
Brooks: Michigan, 24-23
Davis: Michigan, 28-14
Goodbread: Michigan, 20-13
Jeremiah: Michigan, 17-16
Reuter: Michigan, 31-17
Zierlein: Michigan, 31-17

Details: Saturday, 10:15 p.m. ET, ESPN2
What's at stake? It's gut check time (again) for a BYU team that has lost its star quarterback, Taysom Hill, for the season for the second year in a row.
Matchup to watch: Boise State DE Kamalei Correa vs. BYU OL Ryker Mathews.
Game picks:
Brandt: BYU, 30-27
Brooks: Boise State, 31-28
Davis: Boise State, 33-21
Goodbread: Boise State, 30-21
Jeremiah: Boise State, 28-24
Reuter: Boise State, 34-31
Zierlein: Boise State, 28-21

Details: Saturday, 9:15 p.m. ET, ESPN
What's at stake? The loser here isn't out of the SEC West race, but it will have an awfully tough climb back into contention. And after a weather cancellation last week, it's the new season opener for the Tigers.
Matchup to watch: LSU DB Jamal Adams vs. Mississippi State QB Dak Prescott.
Game picks:
Brandt: LSU, 30-20
Brooks: LSU, 24-16
Davis: Mississippi State, 27-24
Goodbread: Mississippi State, 21-16
Jeremiah: LSU, 21-14
Reuter: LSU, 28-24
Zierlein: LSU, 23-21

Details: Saturday, 6 p.m. ET, ESPN
What's at stake? Oklahoma coach Bob Stoops and his record of disdain for SEC hype travel to UT, where the Volunteers have been hyped as much as any team coming off a 7-6 season could hope to be. The conference pride factor will be palpable.
Matchup to watch: Oklahoma RB Samaje Perine vs. Tennessee LB Jalen Reeves-Maybin.
Game picks:
Brandt: Oklahoma, 31-30
Brooks: Oklahoma, 41-28
Davis: Tennessee, 35-31
Goodbread: Oklahoma, 28-20
Jeremiah: Oklahoma, 35-24
Reuter: Tennessee, 34-31
Zierlein: Tennessee, 30-24

Details: Saturday, 8 p.m. ET, ABC
What's at stake? National championship implications await these two legitimate playoff contenders in the best non-conference game that college football's September schedule has to offer.
Matchup to watch: Oregon QB Vernon Adams vs. Michigan State DE Shilique Calhoun.
Game picks:
Brandt: Michigan State, 38-30
Brooks: Michigan State, 35-31
Davis: Michigan State, 40-38
Goodbread: Michigan State, 42-31
Jeremiah: Michigan State, 42-31
Reuter: Oregon, 48-35
Zierlein: Oregon, 24-23