Jahvid Best left the Detroit Lions wondering what could have been after his release Wednesday. Who else is among the most memorable NFL players whose careers ended during their prime?

Jahvid Best was released by the Detroit Lions on Wednesday. The speedy running back, a first-round draft pick in 2010, was beset by concussion problems and missed all of 2012.

Clinton Portis wasn't just one of the NFL's most powerful runners; he also was a punishing blocker. The ex-Washington Redskins running back recently talked about his battles with concussions.

Nate Burleson looks at Reggie Bush and sees the type of versatile player who can return balance to the Detroit Lions' offense the way Jahvid Best once did. Will Burleson's observations be proven true?

Detroit Lions second-round pick Darius Slay reportedly underwent arthroscopic knee surgery recently. The cornerback told Around The League last month that a procedure wouldn't be necessary.

All general managers need a good draft track record to ensure job security. Mickey Loomis is one of five GMs who could find himself on the unemployment line if he fails to hit on his picks.

Jahvid Best's career came to a halt after numerous concussions, but the tailback vows never to give up hope of playing for the Detroit Lions again as he continues to workout.

A lot of NFL players saw their dreams dashed over the last two days. Find out who the biggest names were from our initial wave of cuts.

Jahvid Best hasn't played for the Detroit Lions since October of last year when he suffered a concussion. The running back won't be on the field at least the first six games of the season.

Detroit Lions RB Jahvid Best is still on the mend from a concussion he suffered last season, but coach Jim Schwartz isn't ready to stash him away on the PUP just yet.

Maurice Jones-Drew probably won't be traded, even if he wants to be. But if the Jaguars did honor his request, where could the rushing champ land? Dan Hanzus sorts through the depth charts.

Jahvid Best is likely headed to the PUP list, adding a little clarity to an uncertain running back situation in Detroit. Plus, Roddy White reinforces the idea of Julio Jones' fantasy football evolution.

More problems for Jahvid Best. After starting just 15 games over two seasons, the Detroit Lions running back has yet to be cleared for practice and reportedly could start the season on the PUP list.

The preseason is a time to expose a team's problem, and if you're the Arizona Cardinals, you've got one at quarterback. We've found at least 31 other problems that will keep NFL coaches up at night.

Tim Tebow's preseason debut with the Jets hits some turbulence, Jake Locker is closing in on Matt Hasselbeck and Andrew Luck makes it look easy. Marcas Grant recaps the weekend's preseason games.

How will the New York Jets use Tim Tebow? Is Kevin Kolb or John Skelton the Arizona Cardinals' QB? Can Andrew Luck live up to the hype? Bucky Brooks has storylines for this weekend.

The Cleveland Browns latest update on rookie running back Trent Richardson isn't necessarily the worst news in the world. But as Marcas Grant writes, it's not encouraging, either.

Matthew Stafford directs one of the NFL's most potent passing offenses, but does a suspect Detroit Lions secondary stand a chance against the opposition? Chad Reuter reports from training camp.

Browns running back Trent Richardson has had a ton of fantasy football hype since being drafted. But as Michael Fabiano writes, knee problems could have his stock falling in countless drafts.

Gregg Rosenthal runs down the latest news around NFL training camps. Could the artist formally known as Ochocinco be a No. 1 receiver again?