Vic Fangio's San Francisco 49ers front seven was widely viewed as the NFL's best entering last season.
Now that All-Pro pass rusher Aldon Smith has been suspended for nine games, that won't be the case this season.
In guessing the length of Smith's absence, this was essentially a worst-case scenario.
With All-Pro inside linebacker NaVorro Bowmanstashed on the PUP list for at least six games and run-stuffing nose tackle Glenn Dorseyrecovering from a torn biceps, Fangio will have to make do with less talent for half of the season.
While there is plenty of depth on hand thanks to recent draft picks such as Corey Lemonier, Tank Carradine, Chris Borland and Quinton Dial, the drop-off from first-team All-Pro to role player is steep.
The 49ers have to brace for the possibility that Bowman, the best linebacker we studied on Game Rewind last season, won't be a difference-maker after reconstructive knee surgery.
If Justin Smith takes a step back in his age-35 season, Fangio will have to make scheme adjustments to cobble together an effective pass rush in September and October.
Although Colin Kaepernick's offense should see significant improvement with a healthy Michael Crabtree and the addition of Stevie Johnson, the defense is in jeopardy of slipping out of the top five for the first time in the Jim Harbaugh era.
Every year, at least one of the consensus NFL superpowers takes a step back and -- much to the dismay of its shocked fan base -- misses the postseason.
Gregg Rosenthal suggested on the recent NFC Preview episode of Around The NFL Podcast that the 49ers are the team most likely to fall on hard times in 2014. If they can't adequately replace two of the most dominant defenders in football, that prediction is going to look prescient in four months.
The latest "Around The NFL Podcast" hands out the first annual Preseason Awards and predicts the major winners of the regular-season awards.