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Niners WR Deebo Samuel (calf) to miss multiple weeks 

There are more injury woes for the San Francisco 49ers to contend with at their skill positions.

Wide receiver Deebo Samuel will miss "a couple" of weeks due to a calf strain, head coach Kyle Shanahan announced Monday.

Samuel was injured late in the 49ers' Week 2 loss to the Minnesota Vikings on Sunday.

Samuel's absence, an obstacle to overcome on its own, is magnified with running back Christian McCaffrey already on injured reserve dealing with calf and Achilles injuries.

Through two games this year, Samuel has recorded 13 receptions for 164 yards, both team highs, along with 10 carries for 13 yards and a rushing touchdown.

Samuel's no stranger to injury woes, as he's never played a full regular season since he was drafted by San Francisco in the 2019 NFL Draft's second round.

The 49ers will face a Los Angeles Rams squad this week facing a plethora of injury issues, as well. Going into the NFC West matchup, L.A. will not have wide receivers Puka Nacua or Cooper Kupp, while the Niners will be without CMC and now Samuel.