Quick Take: Colts-Cardinals

It was over when ...
Trying to mount a rally, Cardinals QB Kurt Warner threw an interception to Colts DB Marlin Jackson on the first play of the fourth quarter. The Colts later tacked on three points to take a commanding 31-10 lead with 11:35 left in the game.

Game ball
Colts QB Peyton Manning threw for 379 yards and four touchdowns.

Key stat
The Cardinals turned over the ball three times, including twice inside the red zone. The mistakes proved costly for Arizona and allowed Indianapolis to dictate the pace of the game with a big lead.

Noteworthy
Colts DE Dwight Freeney, who had two sacks, suffered an injury during the second half and didn't return. ... Warner was sacked four times. ... After going 1-2 in the first month last season, the Colts end September 3-0.