Quick take: Seahawks (2-1) at 49ers (2-1)

Last meeting
San Francisco running back Frank Gore rushed for 212 yards and the 49ers scored on four of their first six possession to defeat Seattle, 24-14, last December.

Streaks
The all-time series is knotted at 8-8, but the 49ers swept the season series in 2006. The Seahawks won six consecutive games from 2003-05.

Last week
Matt Hasselbeck threw a 22-yard touchdown pass with just over a minute remaining and the special teams recovered a fumble on the ensuing kickoff as the Seahawks defeated the Bengals, 24-21. ... The 49ers, who opened the season 2-0, struggled in a 37-16 loss at Pittsburgh.

At stake
The Seahawks were average against the NFC West last season (3-3) and already have dropped a road division game to Arizona. The 49ers were a trendy preseason pick, but if the team wants to win the NFC West, they must take care of division opponents at home.

Key matchup:
RB Shaun Alexander vs. LB Patrick Willis. Alexander has 11 touchdowns in 10 career games against San Francisco. Alexander, who will wear a cast on his wrist, has rushed for 493 yards and six touchdowns in his last five games against the 49ers. Pittsburgh's Willie Parker had two huge runs against San Francisco last week. First-round pick Willis leads the 49ers in tackles, three games into the season. The 49ers played well on defense in its first two games, before they ran into (or more appropriately were ran over by) the Steelers last week. Willis will be counted on to stop Alexander.

Key injuries
SEATTLE: WR D.J. Hackett (ankle), TE Ben Joppru (ankle), RB Maurice Morris (hip), RB Shaun Alexander (wrist), T Sean Locklear (knee); SAN FRANCISCO: TE Vernon Davis (knee), WR Jason Hill (hamstring), WR Arnez Battle (groin), WR Darrell Jackson (back), S Michael Lewis (ribs).

Did you know?
QB Matt Hasselbeck has won six of his last seven starts against the 49ers. ... WR Darrell Jackson will be playing against his former team for the first time.