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| Player | Cause/Organization |
|---|---|
| Brandon Aiyuk | Boys and girls club of America |
| Azeez Al-Shaair | Mobilize Love |
| Arik Armstead | Armstead Academic Project |
| Aaron Banks | American foundation for suicide prevention |
| Nick Bosa | More Than 4 Athletics |
| Spencer Burford | Women's Achievement Network & Development Alliance (WANDA) |
| Jake Brendel | Living For Zachary |
| Daniel Brunskill | Brave the Shave |
| Oren Burks | South County Football Alumni Association |
| Tevin Coleman | Sickle Cell Disease Association of America. |
| Ross Dwelley | Autism Tree Project Foundation |
| Jimmy Garoppolo | TAPS |
| Kevin Givens | Mobilize Love |
| Talanoa Hufanga | Tonga Red Cross |
| Drake Jackson | 95 Problems Foundation |
| Dontae Johnson | Lucille Packard's Children Hospital |
| Kyle Juszczyk | Crohn's and Colitis Foundation |
| Javon Kinlaw | CityTeam |
| Taybor Pepper | Ele's Place |
| George Kittle | Merging Vets & Players (MVP) |
| Christian McCaffrey | Christian McCaffrey Foundation |
| Mike McGlinchey | Donor Network West |
| Elijah Mitchell | Dreams Come True of Louisiana, Inc/Mommies Ending Neonatal Death |
| Ambry Thomas | RYSE Inc. (RYSE Center) |
| Malik Turner | Uplifting Athletes |
| Fred Warner | American Cancer Society |
| Trent Williams | Sarcoma Foundation of America |
| Jeff Wilson Jr. | Next Door Solutions to Domestic Violence |
| Mitch Wishnowsky | Project Apis m. |
| Charlie Woerner | Hope 139 House |
| Samuel Womack III | Boys & Girls Club of Silicon Valley |