Runyan bruised his tailbone in a training room fall last week, but played in Philadelphia's 19-16 loss to Chicago. He sat out practice this week and will be re-evaluated once the team arrives in Minnesota.
"We have a long flight up there. We'll keep giving him treatment, and so on, to see how he does," coach Andy Reid said.
The Eagles (2-4) also could be without both of their starting safeties. All-Pro Brian Dawkins, who hasn't played since sustaining a neck stinger in Week 2, is doubtful, though he practiced the last two days.
"He's feeling better all the way around," Reid said. "The stinger part of it, which is the main concern, has gone away. He's getting better."
Safety Sean Considine hurt his ankle in practice Thursday but returned to the field Friday and is also questionable.
Copyright 2007 by The Associated Press
