Game facts: 49ers at Panthers

Cooling off: Since starting last season 14-0, the Panthers are 3-3 (including the playoffs).

Record chasers: Carolina is chasing a record set by the 1970s Steelers for the longest streak of 100+ yard rushing games as a team. The Steelers' streak was 37 consecutive games, while the Panthers' current streak is at 33 games heading into Sunday.

Masters of the takeaway: The Panthers have a league-best 42 takeaways since 2015. In Week 1, their three takeaways tied the Vikings for the highest total in the league.