Home-field advantage: The Patriots are 28-2 at home since 2013 (including playoffs).
Run-heavy offense: New England has the highest rush percentage (54.0) in the NFL this season. The Bills feature the strongest run defense that the Pats have faced yet, allowing just 3.4 yards per carry (T-4th in NFL).
Bend-but-don't-break defense: The Patriots have allowed 5.7 yards per play so far this season (20th in NFL), but they have surrendered just 15 PPG (5th in NFL).