Quick Take: Host Colts roll over Bengals

It was over when ...
The Colts opened the second half with a 15-play, 81-yard drive that resulted in a 2-yard touchdown pass to WR Anthony Gonzalez. The drive took 8:45 off the clock and gave the Colts a 21-3 lead.

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Coming off his worst performance of the season, Peyton Manning picked apart the Bengals secondary, connecting on 26 of 32 passes for 277 yards and three touchdowns.

Key stat
Dwight Freeney and Robert Mathis would not let Bengals quarterback Ryan Fitzpatrick get comfortable. Indianapolis' defensive ends combined for four of the Colts' five sacks.

Noteworthy
The Bengals have not beaten the Colts since 1997, a span of six games. ... The Bengals are 0-7 on the road this season. ... Fitzpatrick finished 18-of-26 for 170 yards and two interceptions before being replaced by Jordan Palmer in the fourth quarter. ... The Colts have won six straight games, including four in a row at Lucas Oil Field. ... Colts safety Bob Sanders returned following a three-game absence, finishing with eight tackles. Center Jeff Saturday missed his second straight game with a calf injury.