Rex Ryan admitted Wednesday it "doesn't look good" for LeSean McCoy's availability this week against the New York Giants.
NFL Media's Rand Getlin reported on Monday that Shady was unlikely to see the field this week as he deals with a hamstring injury.
"He's certainly not 100 percent. We're holding him out from practice. (There is) a real possibility he won't play," Ryan said, via WGR Radio's Sal Capaccio. "Is it worth the time to get him near or 100 percent? We're weighing that right now."
The running back didn't practice on Wednesday.
With McCoy likely out this week, bulldozing power back Karlos Williams is slated to carry the bulk of the workload. The fifth-round pick has rushed for 186 yards on 24 totes (7.8 yards per carry) with three touchdowns in three games.
Ryan also said he's not sure if receiver Sammy Watkins will play this week as he deals with a calf injury. The wideout also missed practice on Wednesday.
Here's the rest of Wednesday's injury news:
- Colts quarterback Andrew Luck was limited in practice with a right shoulder injury, coach Chuck Pagano said. Pagano added he is "supremely confident" that Luck will play Sunday against the Jaguars.
- Victor Cruzwas limited at practice for the Giants but left after he aggravated his injured calf. Coach Tom Coughlin said before practice that Cruz would gradually increase his workload as the week progresses, with the hope he would be ready to suit up against the Eagles.
- Texans running back Arian Foster (groin) is a "game-time decision" for Sunday's game against the Falcons, coach Bill O'Brien said.
- Bears quarterback Jay Cutler (hamstring) and wide receiver Alshon Jeffery (hamstring) were limited in practice.
- Luke Kuechly remained sidelined for the Panthers with a concussion. Running back Jonathan Stewart missed practice after suffering a leg injury Sunday that Panthers coach Ron Rivera described as "not serious."
- Jaguars tight end Julius Thomas underwent surgery on Sept. 1 to repair a finger injury and was expected to take about a month to recover. Thomas hasn't been activated, but he told the media, "The good news is, no bad news. ... But no dates (to return), no nothing. Just waiting to get cleared."
- Eagles linebacker Kiko Alonso's ACL was deemed to be intact after getting a second opinion, NFL Media Insider Ian Rapoport reported. Alonso received a final diagnosis on his condition from Dr. James Andrews. Alonso will play again this season, likely after a month of rehab, Rapoport added.
Wide receiver Riley Cooper (knee) did not practice and running back DeMarco Murray (hamstring) was a limited participant.
- Cornerback Darius Butler returned to practice for the Colts. Butler missed the past two games with a hip injury and will be a welcome addition to a secondary that's been hurting since the season began. Tight end Dwayne Allen (ankle) didn't practice.
- Packers wideout Davante Adams didn't practice, according to coach Mike McCarthy. Adams injured his ankle early in the first quarter of Monday night's win over the Chiefs.
- Falcons linebacker Brooks Reed (groin) was limited in practice, but has a shot to play this weekend, according to coach Dan Quinn.
- Browns quarterback Josh McCown participated fully in practice with a swollen hand, according to coach Mike Pettine. McCown didn't need an MRI.
- Redskins wideout DeSean Jackson is day-to-day with the hamstring injury that's kept him out since Week 1.
- Chiefs cornerback Phillip Gaines tore his ACL and will miss the season, coach Andy Reid told reporters.
- Ravens tight end Crockett Gillmore (calf), offensive tackle Eugene Monroe (concussion), wideout Breshad Perriman (knee) and defensive end Chris Canty (calf) were ruled out for Thursday's game against the Steelers.
- Steelers linebacker Ryan Shazier (shoulder) was ruled out for Thursday's game.
- Falcons wideout Julio Jones (toe/hamstring) didn't participate in Wednesday's practice. Running back Tevin Coleman also didn't practice with a rib injury. Wideout Devin Hester was limited because of a toe injury.
- Vikings wideout Charles Johnson did not practice for the Vikings with a rib injury.
Rapoport reported that wide receiver Jarius Wright (hand) is "expected to miss a game or two" after not participating in practice.
- Cowboys defensive end Jeremy Mincey (concussion) didn't practice.
- The Packers placed tight end Andrew Quarless on IR boomerang with an MCL sprain he suffered in Monday night's win.
- Niners tight end Vernon Davis (knee) did not practice while running back Reggie Bush (calf) fully participated.
