Struggling to set the perfect fantasy lineup? Let us be your guide. Each week the NFL Fantasy staff will provide you with game-by-game, player-by-player matchup breakdowns in this column to help you set a winning lineup. Think of this as the one-stop shop to crushing your opponent in fantasy football.
Now, onto the best and worst Week 2 fantasy matchups.
Seattle Seahawks at Los Angeles Rams: 4:05 p.m. ET on FOX
Russell Wilson, QB -- START: The Rams defense looked timid and gave up a ton of ground to the 49ers offense in Week 1. Even if Wilson is less than 100 percent he should be in your lineup.
Thomas Rawls, RB -- START: He regained the starting job this week and drew a ton of praise from offensive coordinator, Darrell Bevell. The Rams got run over by Carlos Hyde in their opener.
Christine Michael, RB -- SIT: Keep Michael on your roster in the event that Rawls doesn't regain 2015 form or gets hurt again. However, His Wokeness is no longer a fantasy play.
Doug Baldwin, WR -- START: The Rams let up seven catches to Jeremy Kerley in the slot on Monday night. Baldwin should eat this week.
Tyler Lockett, WR -- FLEX: He was just as much a feature on passing plays as Jermaine Kearse and finished just behind Doug Baldwin in passing targets. Lockett has plenty of upside this week.
Rams
Case Keenum, QB -- SIT: Not now, not ever.
Todd Gurley, RB -- FLEX: Playing at home should make the Rams offense look better in Week 2, but you have to be prepared to take those lumps with Gurley this season. The Seahawks let up fewer than 3.0 yards per carry to Arian Foster in Week 1.
Tavon Austin, WR - SIT: After collecting 13 yards on 12 targets in Week 1, it's impossible to play him with confidence.
Tampa Bay Buccaneers at Arizona Cardinals: 4:05 p.m. ET on FOX
Buccaneers
Jameis Winston, QB -- SIT: The ascending young passer chucked four touchdowns in Week 1, but you might want to go away from him this week. The Cardinals defense should force him into mistakes, especially with Patrick Peterson likely shadowing Mike Evans.
Doug Martin, RB -- FLEX: His ceiling might not be high in this contest, but he's still worth playing with expectations kept in check.
Charles Sims, RB -- FLEX: Once again Sims was a big part of the game plan. In a potential shootout like this, he's worth chasing for passing work.
Mike Evans, WR -- FLEX: He should garner the Patrick Peterson treatment in this game, which is frightening. However, Evans is the type of difference-making talent who can still put up a usable stat line in this spot.
Vincent Jackson, WR -- FLEX: With Evans locked up in Peterson's coverage, Jackson should see plenty of rookie corner Brandon Williams, who blew a coverage in Week 1 that resulted in a long Chris Hogan score.
Austin Seferian-Jenkins, TE -- SIT: He scored in Week 1 but didn't even play half the snaps. Approach with caution.
Cardinals
Carson Palmer, QB -- START:Even in a game where he didn't play well, Palmer cracked 18 fantasy points. The Tampa Bay secondary is especially leaky.
David Johnson, RB -- START: He's the top running back in fantasy football. Even though the Buccaneers have a solid front-seven, he's a clear top-five play.
Larry Fitzgerald, WR -- START: He gets a date with a poor Buccaneers secondary after looking like the clear No. 1 receiver in Week 1. Don't sit him now.
Michael Floyd, WR -- FLEX:Floyd is in a nice bounce back spot in wake of a slow debut where he struggled to get open routinely.
John Brown, WR -- SIT: The Cardinals are easing Brown back into the game plan after he missed a ton of time in the preseason. He'll eventually graduate from the bench but you want to see him play a full complement of the snaps before then.
Jacksonville Jaguars at San Diego Chargers: 4:25 p.m. ET on CBS
Jaguars
Blake Bortles, QB -- START: The Chargers allowed Alex Smith to throw for 363 yards last week. Bortles has more weapons and should be able to post a decent stat line.
T.J. Yeldon, RB -- FLEX: Yeldon's not the most exciting fantasy name but if Chris Ivory is out again, Yeldon will see a full workload against a bad run defense.
Allen Robinson, WR -- START: In theory, the matchup might be a tough one for Robinson but the Jaguars wideout has earned weekly must-start consideration.
Allen Hurns, WR -- FLEX: There is certainly a chance that this game turns into a shootout, which means more targets headed in Hurns' direction.
Julius Thomas, TE -- START: Last week proved what many of us believed all offseason -- Thomas is still a talented player who will have a sizable role in the Jaguars offense.
Chargers
Philip Rivers, QB -- SIT: With his best pass-catching weapon sidelined for the season, we could see a decrease in pass attempts. It's a scary thought against an improved defense.
Melvin Gordon, RB -- FLEX: The Chargers might need to consider running the ball more, but game script could make it hard for Gordon to get the desired volume of touches for starting consideration.
Danny Woodhead, RB -- FLEX: Whether in PPR or standard scoring, Woodhead should see more work now that Keenan Allen is gone for the rest of the season.
Travis Benjamin & Tyrell Williams -- SIT: We don't quite know how the target distribution will look in this offense withouth Keenan Allen leading the way. Take a wait-and-see approach with these wideouts this week.
Antonio Gates, TE -- START: The ageless wonder will once again shoulder a large load in the passing game against a unit that has traditionally struggled to cover the position.
Atlanta Falcons at Oakland Raiders: 4:25 p.m. ET on CBS
Falcons
Devonta Freeman, RB -- FLEX: The newly-minted committee in Atlanta won't please Freeman owners, but there could still be an opportunity to produce.
Tevin Coleman, RB -- FLEX: Coleman looks to have locked down a role as the Falcons' pass-catching back and should see targets from Matt Ryan.
Julio Jones, WR -- START: You're starting Julio. End of discussion.
Mohamed Sanu, WR -- START: Sanu played very well last week and deserves to be in your lineup against Oakland this week.
Raiders
Derek Carr, QB -- START:Jameis Winston torched the Falcons defense last week and another young quarterback is poised to do the same in Week 2.
Latavius Murray, RB -- FLEX: It's too soon to be troubled by the presence of Jalen Richard or Jamize Olawale. Murray is still the running back of record in the Raiders offense.
Amari Cooper, WR -- START: Cooper's 137-yard outing looks like the start of a big season. If he can find the end zone against Atlanta, he'll really be off and running.
Michael Crabtree, WR -- START: There is enough volume in the Oakland passing game that both wideouts should be able to produce for fantasy enthusiasts.
Clive Walford, TE -- SIT: Aside from allowing one nice touchdown catch from Austin Seferian-Jenkins, the Falcons locked down the tight end position. You might want to avoid this matchup.
Indianapolis Colts at Denver Broncos: 4:25 p.m. ET on CBS
Colts
Andrew Luck, QB -- START: Yes, the Denver defense is scary, but no, you're not benching Luck. His talented group of pass-catchers combined with his rushing ability will help him maintain a safe fantasy floor.
Frank Gore, RB -- SIT: Gore is running behind a shaky offensive line facing one of the game's elite defenses. He could sneak in a goal-line touchdown, but there are likely better options on most fantasy rosters than Gore.
T.Y. Hilton & Donte Moncrief, WRs -- FLEX: Hilton had a solid outing last year against Denver (five catches, 82 yards), while Moncrief disappointed (three catches, 30 yards). That's in the past, though, and this is now. The Colts passing attack has too much firepower to completely bench, even in a tough matchup.
Dwayne Allen, TE -- START: The tight end position was a fantasy wasteland in Week 1. It's foolish to bench a player like Allen attached a high-octane passing offense who is coming off seeing roughly 13 percent of the team targets. Allen's a low-end TE1 this week.
Broncos
Trevor Siemian, QB -- START (2QB): Last week, the Colts let Matthew Stafford move up and down the field with short-range passes. Siemian averaged a meager 5.6 yards per aimed throw (slightly higher than Stafford). Even if Demaryius Thomas sits or is limited (hip injury), Siemian could be worth a start in 2QB formats of daily fantasy.
C.J. Anderson, RB -- START: Anderson ran like a man possessed, is facing a defense that just let Theo Riddick and Ameer Abdullahrack up 229 yards and three touchdowns against them. Start Anderson and never look back.
Demaryius Thomas, WR -- FLEX (INJURY): Thomas would be a fine start, but a hip injury suffered in the first quarter last week has been limiting him in practice. Monitor his health leading up to Sunday, because while the team expects him to play, injuries like this can linger and flare up at any time.
Emmanuel Sanders, WR -- START: Sanders is almost a must-start this week, especially with Thomas less than 100 percent. The Colts secondary is in shambles after allowing Matthew Stafford to complete nearly 80 percent of his passes for 340 yards and three touchdowns. Even if Sanders doesn't go deep much with Siemian under center, he should see plenty of targets and will be a solid start.
Virgil Green, TE -- START Green is the primary tight end in Denver after playing 71 percent of the snaps in Week 1. He's a fine start this week against a Colts defense that let Eric Ebron catch five passes for 46 yards and a touchdown last Sunday.
Green Bay Packers at Minnesota Vikings: 8:30 p.m. ET on NBC
Packers
Aaron Rodgers, QB -- START: It's not crazy to sit Rodgers this week if you for some reason have another strong quarterback in a great matchup on your roster (Eli Manning, Drew Brees, etc). However, despite Rodgers throws on average 40 yards and .5 touchdowns less per game against Mike Zimmer-led defenses in his illustrious career, his ever-present sky-high fantasy ceiling is worth chasing.
Eddie Lacy, RB -- START: Lacy received 75 percent of the Green Bay backfield touches in Week 1, averaged 4.4 yards per carry, and looked good in the passing game. While the matchup isn't ideal, he's the focal point on the ground for the Packers.
Jordy Nelson, WR -- START: It was great seeing Nelson get back on track with a touchdown catch in Week 1, but he's not quite 100 percent, as evidenced by his 5.3 yards per reception, which was nearly 10 yards lower than his career average (15.27) prior to 2016. Still, he's the lynchpin to this passing attack, and is a must-start.
Randall Cobb, WR -- START: Cobb didn't have a huge game in Week 1, but he led all Packers wide receivers in snaps and saw 24 percent of the targets. He was open in the end zone, too, but he and Rodgers couldn't connect. He'll be a solid WR2 play this week, with an added boost in PPR formats.
Jared Cook, TE -- SIT: All season we built up Cook's hype train, but so far it hasn't left the regular-season station. The Vikings' young, athletic defense will be a solid match for Cook. Until we see him command more than two targets in a game, he should be left on the bench.
Packers D/ST -- START: The Packers' revamped front seven kept the Jacksonville ground game in check and harrassed Blake Borltes in Week 1. Facing the aging Shaun Hill or still-learning-the-playbook Sam Bradford makes for an enticing fantasy matchup.
Vikings
Vikings starting QB -- SIT: Mike Zimmer isn't naming a starting quarterback until Sunday. You don't need to wait that long to name your fantasy starter. Literally pick any other quarterback in the NFL.
Adrian Peterson, RB -- FLEX: Peterson's putrid Week 1 performance (19 attempts, 31 yards, 1.63 ypc) has plenty of fantasy owners panicking, and the Week 2 matchup isn't much better. The Packers stuffed T.J. Yeldon last week, holding him to 1.86 yards per carry on 21 attemps. Peterson is the primary driver of the Minnesota offense though, and is worth flex consideration on volume alone.
Stefon Diggs, WR -- FLEX: Diggs' breakout season got off to a great start in Week 1 as he saw over 27 percent of the team target and notched a stellar 11.4 yards per target. While Green Bay boasts a talented young secondary, Diggs is a decent option in standard and PPR formats as the No. 1 wide receiver in Minnesota.
Kyle Rudolph, TE -- START: Rudolph saw the second-most targets on the team in Week 1 (eight), and is facing a Packers defense that allowed Julius Thomas and Marcedes Lewis to rack up a combined 112 yards and a touchdown on seven targets. Given the disaster the tight end position produced last week, Rudolph warrants a start.
Vikings D/ST -- START: While the Vikings defense isn't likely to score two touchdowns again as they did in Week 1, they're worth a start thanks to Mike Zimmer's ability to keep Aaron Rodgers in check.
Philadelphia Eagles at Chicago Bears: 8:30 p.m. ET on ESPN
Eagles
Carson Wentz, QB -- START (2QB): Yes, Wentz whomped the Browns last week, but his performance was encouraging, especially as he completed five of his six attempts of 15-plus yards downfield. Brock Osweiler found success against this Bears defense last week, so those in deeper or 2QB formats should feel OK about trotting out Wentz.
Ryan Mathews, RB -- START: Mathews is the featured back in this offense, and so far has a stranglehold on red-zone touches (saw 100 percent of the carries, and 78 percent of all opportunities). Lamar Miller did work against the Bears front seven last week, so Mathews should find at least enough space to put up RB2 numbers.
Darren Sproles, RB -- SIT: While Sproles led the backfield in snaps in Week 1, he didn't see a ton of touches and a slow-paced matchup against the Bears doesn't favor Sproles from a fantasy perspective. Leave him on the bench for Week 2.
Jordan Matthews, WR -- START: While we thought Matthews was pigeon-holed as a slot receiver, he appears to be spreading his wings under Doug Pederson, as he played more snaps outside (36) than in the slot (31) in Week 1. Matthews' new-found versatility as the No. 1 receiver for Wentz makes him a nice start against a banged up Chicago secondary.
Nelson Agholor, WR -- FLEX: With Zach Ertz likely to miss this game, Agholor could see his target share (13.5 percent in Week 1) climb toward the 20 percent range in Week 2, making him a much more viable starting option, especially as a flex play.
Bears
Jay Cutler, QB -- SIT: Despite being down for much of his Week 1 game, Cutler still threw the fourth-fewest passes in the NFL in Week 1 (29, tied with Ryan Tannehill). He lacks the volume and weapons to be a weekly starter in fantasy.
Jeremy Langford, RB -- START: While Langford continued his inefficient ways from last season (3.6 yards per carry in Week 1), he saw 87.5 percent of the backfield opportunities (targets and carries), and scored a touchdown. Even if he plods along like that each week, he'll be fantasy relevant on volume alone.
Alshon Jeffery, WR -- START: Jeffery got off to a hot start in Week 1 with 105 yards in the first half, but was blanked in the second (he only saw two targets after half time). Still, he's the top option in this offense and if things go bad for Cutler, we know he's always looking for Jeffery.
Kevin White, WR -- SIT: White's "rookie" debut was uninspiring, as he caught just three of a team-high seven targets for 34 yards and caused an interception with a bad route. Until he starts putting it together on the field, he shouldn't have a spot in fantasy lineups.
Zach Miller, TE -- SIT: We'd hoped Miller's strong finish to the 2015 campaign would carry over into 2015, but four targets in Week 1 have us a bit worried. He could bounce-back soon, but let him sit on the bench and stream the position until Miller catches fire again.
Completed Week 2 games
New York Jets at Buffalo Bills: 8:25 p.m. ET on NFL Network, CBS and Twitter
Jets
Ryan Fitzpatrick, QB -- SIT: Unless you play in a 2QB league, you should be able to find options with a higher ceiling than Fitzpatrick. He'll keep Brandon Marshall and Eric Decker relevant but as our consensus ranked QB22 for the week, he's better off left on the bench.
Matt Forte, RB -- START: Forte was just about the only good thing the Jets had going on offense last week. On a short week, he might not see a 27-touch workload again, but should be just fine as an upside RB2.
Brandon Marshall, WR -- START: BMarsh was shut down in Week 1 by the Bengals defense. Don't expect that to happen again. He's a must-start against Buffalo and has WR1 upside.
Eric Decker, WR -- START: This dude is a touchdown machine. He started the season with one last week, and there's no reason he can't keep rolling against a decimated Buffalo defense on Thursday night.
Bilal Powell, RB -- FLEX: He should be more involved against the Bills on Thursday night than in Week 1. The Jets will want to manage Forte's workload and that means more opportunities for the explosive change-of-pace Powell, who has PPR upside.
Bills
Tyrod Taylor, QB -- SIT: With Sammy Watkins highly questionable with a foot injury, Taylor's fantasy value is a mystery. The smart move is benching Taylor against a tough Jets defense (Jets D/ST is a top streaming option this week).
LeSean McCoy, RB -- FLEX: If Watkins does sit, McCoy will be fed the rock early and often. He's listed as a flex because he'll be the only real concern for the Jets defense, so they should game plan to shut him down. His projected volume makes him viable.
Sammy Watkins, WR -- SIT: Steer clear of this situation at all costs. Watkins' status (foot) will come down to a game-time decision and that's never a good sign. Even if he does play, it's hard to believe he will be much more than a decoy.
San Francisco 49ers at Carolina Panthers: 1:00 p.m. ET on FOX
49ers
Blaine Gabbert, QB -- SIT: Gabbert was passable last week against the Rams. These ain't the Rams.
Carlos Hyde, RB -- SIT:C.J. Anderson's big game against the Panthers was a surprise. Hyde doesn't seem likely to reproduce those numbers
Torrey Smith, WR -- FLEX: Smith's value could come late as the Niners throw the ball in an attempt to catch up.
Jeremy Kerley, WR -- FLEX: After getting a team-high 11 targets in Week 1, it looks like Kerley could be a bigger part of the passing game than expected. But don't get crazy.
Vance McDonald, TE -- SIT: McDonald trailed blocking tight end Garrett Celek in targets. It might not happen again, but we still can't recommend McDonald this week.
Panthers
Cam Newton, QB -- START: Even against arguably the best defense in the league, Newton found a way to score 21 fantasy points. The Niners don't portend to offer that level of resistance.
Jonathan Stewart, RB -- START: Stewart dominates the running back carries in the offense, but he'll still occasionally lose out to Carolina's dynamic quarterback in scoring situations.
Kelvin Benjamin, WR -- START: Last week's 16-point performance was a reminder to all who doubted Benjamin this summer. There's more where that came from.
Greg Olsen, TE -- START: One of the NFL's best tight ends is a weekly must-start.
Panthers D/ST -- START: They might have allowed 21 points last week, but this group still gets after the quarterback and forces turnovers. Sit 'em at your own peril.
Dallas Cowboys at Washington Redskins: 1:00 p.m. ET on FOX
Cowboys
Dak Prescott, QB -- SIT:Big Ben shredded the Washington secondary, but Dak is no Big Ben. He won't be able to challenge and beat Bashaud Breeland and Josh Norman like Roethlisberger did, especially if he gives 26 targets to Cole Beasley and Jason Witten again. Leave Dak on the bench for Week 2.
Ezekiel Elliott, RB -- START: Do. Not. Panic. Elliott will be fine in fantasy, he just had a rough combination of rookie jitters and a matchup with the sneakily strout Giants defensive line. Washington was gashed by the 33-year-old DeAngelo Williams in Week 1, so fire up Zeke with confidence.
Dez Bryant, WR -- FLEX: The Cowboys' insistence that they won't feed Bryant targets is troubling in real and fantasy football. Even if he sees minimal targets again, his red-zone dominance merits flex consideration at worst. Hey, Dallas, a word of advice? #JustThrowItToYourGoodPlayers.
Jason Witten, TE -- START: Witten is worth a start after seeing 31.1 percent of the team targets in Week 1. Young passers often lean on tight ends as security blankets, giving Witten an added boost in PPR formats.
Cole Beasley, WR -- SIT: Beasley is worth a look in deeper PPR formats, but fantasy owners can likely find better production elsewhere.
Redskins
Kirk Cousins, QB -- SIT: Cousins was scattershot in Week 1, despite playing with a loaded pass-catching corps. With Dallas likely slowling the game down again (36:43 time of possession in Week 1) to protect their leaky defense and rookie quarterback, Cousins will have even fewer chances to score. He's a sit this week.
Matt Jones, RB -- SIT: Jones picked up where he left off in 2015, averaging a pedestrian 3.4 yards per carry. He's nursing a shoulder injury and loses pass-catching work to Chris Thompson. He's hard to trust right now.
Chris Thompson, RB -- LOW-END FLEX (PPR): Even though Thompson only saw one more target than Jones in Week 1, he's the more dynamic pass-taching option. He'll see a few carries as well, helping his weekly floor. He's not an exciting option right now, but he's there if you need him.
DeSean Jackson, WR -- START: Jackson looked strong in the season debut, stretching the field and seeing work in the intermediate areas as well. He's an excellent WR2-3 or flex play given his big-play nature, and his floor in this offense feels safer than in years past.
Jordan Reed, TE -- START: Reed is a mismatch at tight end and one of Cousins' favorite targets (team-high 11 looks in Week 1). Even though he disappointed a bit out of the gate, he needs to be started on a weekly basis.
Jamison Crowder & Pierre Garcon, WRs -- FLEX (PPR): Crowder and Garcon both logged six catches last week, though Crowder saw 10 targets, second-most on the team with Jackson. Both are worth a look in PPR formats, though it appears Crowder's floor is a bit safer that Garcon's.
Cincinnati Bengals at Pittsburgh Steelers: 1:00 p.m. ET on CBS
Bengals
Andy Dalton, QB -- START:Word on the street is Dalton is finally coming into his own as an NFL quarterback. And when he's got a guy like A.J. Green to sling it to, he'll have top-10 upside in fantasy on a weekly basis.
A.J. Green, WR -- START: Green had 12 catches for 180 yards and a score last week. Dalton has tunnel vision for his best wideout and fantasy owners will reap the rewards.
Jeremy Hill, RB -- LOW-END FLEX: As was the case last year, Hill's fantasy value still seems very touchdown dependent. He fell into the end zone last week, but if you flex him, just realize his floor is basement-level if he doesn't score.
Giovani Bernard, RB -- FLEX: Expect Gio to bounce back following a game in which he had just seven touches against the Jets. The Bengals will need to get him involved more if they want any chance at keeping up with the Steelers' high-flying offense.
Steelers
Ben Roethlisberger, QB -- START:Big Ben is a weekly top-10 play at quarterback as long as Antonio Brown is on the field. Slot him into your lineup and watch him drop dimes on Sunday at home.
Antonio Brown, WR -- START: The best wide receiver in the NFL and arguably the most valuable player in fantasy football, Brown is a set-it-and-forget-it roster lock each and every week. His floor is like, 200 yards or something.
DeAngelo Williams, RB -- START: Fire up Williams as an RB1 against the Bengals who allowed Matt Forte to shred them for 155 yards from scrimmage last week. He'll have a huge workload for the second straight week and has top-five upside at his position.
Jesse James, TE -- SIT: If you're absolutely desperate for a tight end, James has a decent floor. But that's only if you're desperate, which you shouldn't be yet since it's only Week 2.
Eli Rogers, WR -- FLEX: Rogers had a solid role out of the slot in the Steelers' passing game in Week 1, although his touchdown catch was somewhat of a fluke. He gets flex consideration since it seems like Pittsburgh wants him to be a big part of this offense.
New Orleans Saints at New York Giants: 1:00 p.m. ET on FOX
Saints
Drew Brees, QB -- START: Last season in this matchup, Brees went for seven touchdowns. That seems unlikely, but he should still be pretty productive.
Mark Ingram, RB -- FLEX: Ingram will see the lion's share of the backfield snaps, but beware of New York's improved front line with run stuffer Damon Harrison.
Travaris Cadet, RB -- FLEX: With C.J. Spiller gone, Cadet locks up the role of the Saints' pass-catching back. He could see work in a potentially high-scoring game.
Brandin Cooks, WR -- START: Cooks tied with Willie Snead as the most-targeted Saints player in Week 1. Brees spreads the ball around, but Cooks remains one of his favorite targets.
Willie Snead, WR -- START: Are we done sleeping on Willie Snead? He's a legit contributor and warrants weekly starting consideration in all formats.
Michael Thomas, WR -- FLEX: Thomas' week to week production could be inconsistent, but the Saints aren't afraid to go to the rookie. He should get consideration again this week.
Coby Fleener, TE -- SIT: Wake us when he makes a play in this offense.
Giants
Eli Manning, QB -- START: Last season, Manning dropped six touchdowns on the Saints. Considering the state of New Orleans' defense, he could flirt with it again this week.
Odell Beckham, Jr., WR -- START: Only OBJ could cause a freakout by scoring "just" 7.30 fantasy points. You're starting him this week. You know it and we know it, and you know we know it.
Victor Cruz, WR -- START: It was great seeing Cruz salsa dancing yet again. Look for the Giants to continue to get him involved.
Sterling Shepard, WR -- FLEX: The rookie will likely continue to work in slowly. But against a bad defense like the Saints, that could still mean quality production.
Rashad Jennings, RB -- START: Did we mention that the Saints defense is bad? Because it is. Jennings quietly had a nice game in Week 1 and should do the same in Week 2.
Shane Vereen, RB -- FLEX: This is mostly for the PPR crowd, but Vereen should see a healthy number of targets again this week.
Miami Dolphins at New England Patriots: 1:00 p.m. ET on CBS
Dolphins
Ryan Tannehill, QB -- SIT: On the road against New England is not a spot to start an average fantasy quarterback, especially when he has limited cupboard of pass-catchers to work with.
Arian Foster, RB -- START: Foster is another player that you probably want to make best use of while he's healthy. He's the clear feature back after playing on 87 percent of the Dolphins' snaps in Week 1. He has a defined role as a passing-down back, as well, and the Dolphins figure to be trailing against a still solid New England scoring unit.
Jarvis Landry, WR -- FLEX: As per usual, Landry led the team in targets but failed to crack 60 yards on seven receptions in Week 1. New England will likely look to limit big play options in Miami's offense and be content to cede short throws to Landry, much like they were with Larry Fitzgerald last week.
Kenny Stills, WR -- SIT: He's the clear No. 2 receiver in this passing game but still doesn't merit fantasy consideration in a matchup like this.
Patriots
Jimmy Garoppolo, QB -- START: He's not a priority start but if you're streaming quarterbacks, Garopplo merits consideration. The Dolphins secondary is still a liability and the Patriots dialed up plenty of short throws to elevate their new starter's floor.
LeGarrette Blount, RB -- START: Despite his mediocre reputation, Blount is completely fantasy viable in games where New England is expected to win. This week fits that mold and Blount was a workhorse back in Week 1 handling over 20 carries.
Julian Edelman, WR -- START: He led the team in targets and did not look lost in this offense without Tom Brady.
Rob Gronkowski, TE -- START: If Gronk plays for the Patriots, he plays for your fantasy team.
Martellus Bennett, TE -- SIT: Even if Gronk sits again, Bennett is a risky fantasy play. He started in place of the All-Pro last week but was often left in to block in wake of a number of tackle injuries in New England.
Kansas City Chiefs at Houston Texans: 1:00 p.m. ET on CBS
Chiefs
Alex Smith -- SIT: For those who had the guts to start Smith in Week 1, kudos to you. He lit up in the second half and led his team to a comeback win at home. He might find it a bit harder to produce against a solid Texans defense on the road.
Jeremy Maclin -- FLEX: As the Chiefs No. 1 wideout, Maclin should be started each and every week. He gets a FLEX tag this week in a tough matchup against Houston, but we wouldn't be surprised if he out-performed expectations.
Spencer Ware -- START: Ware raked as a pass-catcher last week with 129 receiving yards as the Chiefs were climbing out of a 21-point hole in the second half. He added 70 rush yards and a touchdown to finish as the RB3 overall for Week 1. He should shoulder a heavy workload again versus Houston, so lock him in as an RB1.
Travis Kelce, TE -- START:Kelce is good for about 60 to 70 yards on a weekly basis and if he gets into the end zone, he's a top-10 tight end. He needs to be started given the lack of other talented pass catchers in Kansas City.
Texans
Brock Osweiler, QB -- SIT:Osweiler was a decent streaming option in Week 1 if you needed help, but we're not ready to anoint him as a weekly play just yet. Let him fester on the waiver wire for now.
Lamar Miller, RB -- START:Lamar Miller is going to eat against a depleted Kansas City linebacker unit that is without Justin Houston, Josh Mauaga and is using Tamba Hali on limited snaps. Miller logged 32 touches in Week 1 and it's obvious that the Texans are going to feed him a huge workload. He's a locked-in RB1.
DeAndre Hopkins, WR -- START: Despite having a legitimate receiving option on the opposite side of the field (Will Fuller), Hopkins remains a weekly must-start no matter what the matchup. He'll be peppered with targets all year, especially in the red zone.
Will Fuller, WR -- FLEX:In his rookie debut, Fuller led Houston in targets and collected over 100 yards and a touchdown. We'd like to see him do it again before we call him a weekly starter, but you're safe plugging him in as a flex this week.
Tennessee Titans at Detroit Lions: 1:00 p.m. ET on CBS
Titans
Marcus Mariota, QB -- SIT: The Vikings were able to knock Mariota off his script far too easily in Week 1. He'll likely see a ton of pressure once again this week while his team looks to turn back to the ground game.
DeMarco Murray, RB -- FLEX: If you have Murray you want to make use of him while he's still the clear-cut starter. Nothing about this spot screams that he's a great play, but running back options are slim.
Derrick Henry, RB -- SIT: As long as he's the No. 2 back on the Titans, Henry remains a boom-or-bust weekly flex play.
Tajae Sharpe, WR -- FLEX: Week 1 confirmed what the preseason hinted: Tajae Sharpe is the No. 1 receiver on this team. Sharpe led the team in targets last week and the Titans should be playing catchup this game against a high-flying Detroit offense.
Delanie Walker, TE -- START: It was a down first game for Walker, but he looks like a fine bounce-back candidate this week. The Lions allowed three touchdowns to tight ends in Week 1.
Lions
Matthew Stafford, QB -- START: The Lions are not only pass-heavy but also built around high percentage throws. It looks like Stafford is trending toward every-week starter status, especially this week against a defense that made Shaun Hill look serviceable.
Theo Riddick, RB -- FLEX: The Lions played the Colts in Week 1, so their running back production comes with a caveat. However, Riddick looked like a mainstay in the passing game and that is unlikely to change.
Ameer Abdullah, RB -- SIT: Abdullah scored his Week 1 touchdown when Riddick was in the locker room being tested for a concussion. The Titans did a solid job shutting down the run in Week 1 so we'd advise just monitoring Abdullah's usage in Week 2 to get a batter sense of his value going forward.
Marvin Jones, WR -- START: Jones led the Lions in targets last week and was the only player with an average depth of target greater than seven yards down the field. The Titans couldn't contain Stefon Diggs in Week 1, who went for over 100 yards.
Golden Tate, WR -- FLEX: Tate caught all seven of his targets for under 50 yards. He has a high floor every week but needs the Lions to get into red-zone situations to access his ceiling considering he isn't used down the field.
Eric Ebron, TE -- START: Despite missing a ton of practice time in the preseason, Ebron played 92 percent of the Lions' snaps in Week 1. He also snared a red-zone touchdown. With how often this offense throws, Ebron is trending toward every-week starter status.
Baltimore Ravens at Cleveland Browns: 1:00 p.m. ET on CBS
Ravens
Joe Flacco, QB -- START:The Browns defense made Carson Wentz look like a viable fantasy starter in his NFL debut. Joe Flacco is elite. You do the math.
Mike Wallace, WR -- FLEX:Wallace might be the only trustworthy wideout in Baltimore from a fantasy perspective. He flashed his big-play ability a week ago, and odds are he'll be able to get behind Cleveland's secondary for another trip to the end zone in Week 2.
Ravens WRs -- SIT: Between Steve Smith Sr., Kamar Aiken and Breshad Perriman, there's just too much unknown in terms of target distribution to safely start any of these guys.
Browns
Josh McCown, QB -- SIT: McCown might bring up the value of guys like Gary Barnidge and Duke Johnson, but we're not so sure he can hold his own as a fantasy starter. Leave him on the waiver wire for now.
Corey Coleman, WR -- FLEX: As the top target in Cleveland, Coleman is worth a shot in your flex. Josh McCown might help the talented youngster have a solid rookie campaign.
Gary Barnidge, TE -- START: After putting up a goose egg last week, the outlook for Barnidge is much brighter with McCown under center. Cleveland beat writer Mary Kay Cabot even said he could return to his "Pro Bowl form" if McCown stays healthy. Plug him in as a top-10 option at the position.
Isaiah Crowell, RB -- FLEX: Crowell's weekly upside is capped buy his limited volume as a runner. It's hard to imagine him logging 15 or more carries, but he did manage to score on just 11 attempts last week, so it's not out of the question.
Duke Johnson, RB -- FLEX: If the Browns want to win games, they need to get Johnson the ball more than the six times he touched it a week ago. With McCown now under center, Johnson is a much safer flex play than he was with RGIII starting.
