This marks the first time San Francisco has been at .500 at the season's midpoint under Jim Harbaugh. The 49ers were 7-1 in 2011 and 6-2 each of the last two seasons. This is only the fourth time the 49ers have lost consecutive games under Harbaugh. The team has never lost three straight games under Harbaugh.

The last time the Cardinals were 7-1 was 1974, when they finished 10-4 under Don Coryell. Jim Hart was quarterback, Terry Metcalf and Jim Otis were running backs and Mel Gray was a wide receiver. That team also featured Conrad Dobler and Hall of Famer Dan Dierdorf on the offensive line. The Cardinals are 5-0 vs. the NFC this season, and are the only team in the NFL without a conference loss. The Cardinals (7-1) own the best record in the league and this marks the first time that the Cardinals have had the best record in the NFL outright in November or later since 1966, when they started 7-1-1.

The Browns have lost 17 straight road games in the AFC North, which is the longest losing road streak for one team against division opponents since the merger. The Browns' last win in the division: Week 4, 2008 at CIN (20-12), when Derek Anderson beat Ryan Fitzpatrick. The Bengals are 13-0-1 in their last 14 regular season home games (regular season only). In those 14 games, the Bengals average 32.3 ppg, hold their opponents to 18.0 ppg, and have a turnover differential of +10.

Eli Manning has 159 career starts. With Sunday's start in Seattle, he will edge Phil Simms for the most in Giants history by a quarterback.

The Jaguars have the NFL's best red zone defense, allowing a touchdown on only 40 percent of opponent's red zone drives.

LeSean McCoy has more than doubled his rushing yards over the last four weeks, from an average of 48 yards per game (Weeks 1 to 4) to 107.5 yards per game.

Matt Forte's 58 receptions put him second in the NFL. He is on pace for 116 receptions, which would be the most ever by a running back by a whopping 15 receptions. Larry Centers caught 101 passes for the Cardinals in 1995. LaDainian Tomlinson caught 100 for the Chargers in 2001.

Ben Roethlisberger has 12 TD passes in his last 2 games; the New York Jets have 12 TD passes in their last 15 games.

Would you have guessed this game features the NFL's two best red zone offenses? The Broncos have scored a touchdown on 81.5 percent of their 27 red zone drives. The Raiders have scored a TD on 76.9 percent of their 13 red zone drives.

Seahawks quarterback Russell Wilson has 158 rushing yards on third down, which is the most in the NFL among all players and 41 more yards than the next player on the list, Arian Foster (117).