Over the course of the NFL's first 96 seasons, only 3 players have ever amassed 400 career passing touchdowns: Peyton Manning, Brett Favre, and Dan Marino. Over the course of mere minutes on Sunday last week, two more could join that list. Drew Brees needs 3 passing touchdowns to join the 400 club, while Tom Brady needs 4.

Since Russell Wilson was drafted in 2012, the Seahawks are 3-0 against Aaron Rodgers and the Packers. The Seahawks are outscoring the Packers by almost 10 PPG in those games (26.0 to 16.7).

The last four games between a Rex Ryan-led team and the Patriots have been decided by a total of 9 points, with the Patriots winning 3 of those 4 games. None of those individual games has been decided by more than 3 points.

The Rams and Redskins will face off in Week 2, over three years after a trade between the two teams brought Robert Griffin III to Washington. Griffin has made 35 career starts with the Redskins, while the eight players the Rams ultimately acquired using the picks from the deal (including current starters CB Janoris Jenkins, DT Michael Brockers, LB Alec Ogletree and LT Greg Robinson) have made a combined 158 starts for the team.

The Jaguars have allowed at least 4 sacks in eight straight games, the longest active streak in the NFL. No other team has allowed 4-plus sacks in even their last two games. Blake Bortles has been sacked more in that span of 8 games (41 times) than Peyton Manning has been sacked in his last 35 games combined.

With Manziel starting for the Browns, Mariota will be the first Heisman-winning quarterback in NFL history to face two former Heisman-winning QBs in back-to-back games... That's at any point, let alone in his first two NFL games.

DeMarco Murray will become the first player in NFL history to rush for 1,500 yards, change teams and then face his former team the following season. Murray led the NFL with 1,845 rushing yards last season.

Over the last five seasons, teams make extra points at a rate of 99.4 pct -- So far in 2015, with the longer extra point, teams are 71/75 (94.7 pct)

The Jets and Colts game is the second of 19 Super Bowl rematches to be played this season -- Super Bowl III (NYJ 16, IND 7). The most recent matchup was a Jets' 35-9 win over the Colts in Week 6 of 2012 (Andrew Luck's rookie season) -- Luck: 22-of-44, 280 yards, 0 TD, 2 INT -- Sanchez: 11-of-18, 82 yards, 2 TD, 0 INT. The Jets were first team to not allow a TD pass to Luck.