This will be the first Colts-Broncos game without Peyton Manning involved since Week 5, 1993, when John Elway was the Broncos starting QB and Tim Allen's Home Improvement was the No. 1 sitcom on TV.

Is there a better QB-WR duo in the NFL than Ben Roethlisberger and Antonio Brown? Over the last 16 games they've played together, Brown has amassed 151 receptions and 2,048 receiving yards, both of which would be NFL single- season records.

Aaron Rodgers is 1-4 in his last 5 primetime games (including playoffs), with 6 TD, 4 INT, and a passer rating of 77.6. In his previous 24 primetime games, Rodgers was 18-6 with 59 TD, 8 INT.

Sammy Watkins caught 7 of 10 targets for 111 yards when covered by Darrelle Revis in their last matchup (Week 17, 2015). In Revis' last two games, when covering Watkins and A.J. Green, he allowed 17-of-20 passes to be completed for 263 yards and a TD for a passer rating allowed of 135.4.

Russell Wilson has more losses (4) against the Rams than he does against any other opponent. He's also been sacked more by the Rams than any other team (35 sacks in 8 games).

Hey Rookie, it's not the preseason anymore! After completing all three of his pass attempts to Dez Bryant (including two for TDs) in the preseason, Dak Prescott was just 1-for-5 for 8 yards targeting No. 88 in Week 1 vs the Giants.

According to Next Gen Stats, Jimmy Garoppolo had a passer rating of 145.0 against the blitz on Sunday, good for the best passer rating of any quarterback against the blitz in Week 1. He faced a blitz-happy Cardinals defense that rushed 5+ defenders 10 times on pass plays during the games.

Will Drew Brees and Eli Manning continue their aerial assault from their last meeting? In Week 8, 2015, Brees threw seven pass TDs (tied single game NFL record) and Manning threw six. The combined 13 pass TDs were the most by opposing QBs in a single game in NFL history.

After starting the 2015 season with 14 straight wins, the Panthers are 3-3 in their last 6 games (including playoffs). In that span, Cam Newton has 6 passing touchdowns and 6 giveaways.

Carson Wentz showed off an accurate deep ball in Week 1 against the Browns, completing 9 of 11 pass attempts of 10+ air yards. Those passes went for 172 yards and 2 TD, giving Wentz a perfect 158.3 passer rating on those throws.