Brandon Weeden has a tough task ahead of him Sunday. Weeden is 5-18 (.217) in his career. Quarterbacks to enter a game against Bill Belichick's Patriots with a career winning percentage of less than .250 are 1-10 with nine touchdowns and 11 interceptions in those games.

Marcus Mariota can continue to set rookie records if he has an impressive performance in the Titans' fourth game. He is currently tied with Hall of Famer Dan Marino for most touchdown passes thrown by a rookie in his first three starts (8), and if Mariota throws three touchdowns against the Bills, he will break Marino's record for most in a rookie's first four starts (10). Given the fact that the Bills have the league's 29th-ranked pass defense and have given up more passing touchdowns (10) than all but one other team, Mariota could have a shot at breaking another record this Sunday.

Todd Gurley made a major impact in his first career start by rushing for 146 yards. Gurley now has more rush yards this season (155) than notables such as: LeSean McCoy (146), Lamar Miller (131), Marshawn Lynch (128), C.J. Anderson (117) and DeMarco Murray (47).

Devonta Freeman has three rushing touchdowns in consecutive games. It's the first time someone has done that since NFL Media's LaDainian Tomlinson accomplished the feat back in Weeks 9, 10 and 11 in 2006 when he did so in three straight games.

DeMarco Murray has just 29 carries this season. That's the second-fewest for a defending rushing champ in his first three games since 1970. And remember, none of the previous six RBs to log 390-plus carries in a season followed that up with a 1,000-yard campaign (Murray: 392 carries in 2014).

The Cardinals are looking to avoid losing back-to-back games. That is something that has only happened once since Bruce Arians took over in 2013 with Carson Palmer as their starting quarterback. They lost consecutive games to the 49ers and Seahawks in Weeks 6 and 7 in 2013. The Cardinals defense has returned three interceptions for touchdowns this season. There are 20 NFL teams that only have three or fewer interceptions all season.

The Broncos have won 13-straight divisional road games, which is the longest such streak in NFL history. The last time they lost in the division on the road was at Oakland in 2010, but Tim Tebow was at quarterback.

Le'Veon Bell compares favorably to NFL Media's LaDainian Tomlinson through their first 31 career games. Bell has rushed for 2,412 yards compared to 2,852 for Tomlinson, but Bell has amassed more yards from scrimmage (3,756 to 3,690).

Kansas City has allowed 30-plus points in three-straight games this season. It did not allow 30-plus points in any games in 2014. In 840 games in KC franchise history, the Chiefs have never allowed 30-plus points in four-straight games.

The Seahawks are one of three teams without an interception this season (Saints and Redskins). From 2011 to 2014, Seattle led the NFL with 81 interceptions.