Since John Pagano joined the Chargers defensive staff in 2002, Peyton Manning has struggled vs San Diego. Manning is 6-6 vs the Chargers, but 145-46 against all other teams - including the playoffs. His ratio of TD to INT is 1.35:1 vs San Diego, but 2.81:1 against all other teams. And his passer rating of 88.1 is almost 14 points worse against Pagano's Chargers than it is against all other teams (101.8), since 2002.

Joe Flacco has struggled in his career vs the Bengals, throwing more than twice as many INT against Cincinnati (16) than any other team. He will be in good company on Sunday; Andy Dalton has more INT vs Ravens (11) than any other team.

The Bills have not sacked a Jets QB in New Jersey since Week 17, 2010, when they got to Mark Brunell. And in the Bills only game against the Giants at MetLife Stadium, they did not record a sack, which means Buffalo has a total of 1 sack in 5 games at MetLife, which opened in 2010.

The Eagles have a takeaway in every game this season. The Cardinals offense has thrown 1 INT, which is the fewest in the NFL.

Brandon Marshall has had 135+ receiving yards in each of his last two games vs Patriots. He is one of six players to record 100+ receiving yards in consecutive games against a Bill Belichick-coached team, joining Demaryius Thomas, Vincent Jackson, Reggie Wayne, Rod Smith and Marvin Harrison, who had 100+ receiving yards in consecutive games on two separate occasions vs Belichick. No player has ever had 100+ receiving yards in 3 straight games against a Belichick-coached team.

In the three head-to-head matchups between Aaron Rodgers and Drew Brees, the home team has won each game. Although Rodgers is 2-1 in those games, Brees has the better numbers, including 10 TD, 0 INT and a passer rating of 122.5 to Rodgers' 9 TD, 4 INT and a passer rating of 102.5.

The Cowboys have not beaten a team this season that currently has a winning record -- TEN (2-5), STL (2-4), NO (2-4), HOU (3-4), SEA (3-3) and NYG (3-4).

The Chargers are trying to avoid back-to-back losses. Historically, facing Peyton Manning is not the solution this predicament. Teams are 24-88 (.214) vs Manning when coming off a loss. Since Manning joined the Broncos, teams are even worse - 3-20 against Manning when coming off a loss.

Last week, Kyle Orton threw the ball 43 times, completing 72.1% of his passes. It was the highest completion pct for a Bills QB with 40+ attempts since Jim Kelly in 1994 (72.7% on 44 attempts in Week 12 vs Packers)

The Seahawks have won 3 straight games against the Panthers. The last time Carolina beat Seattle, (Week 15, 2007 -- CAR 13, SEA 10), Matt Moore beat Matt Hasselbeck.