The Packers/Falcons game features a matchup of 2 of the last 3 NFL MVPs in Matt Ryan (2016) and Aaron Rodgers (2014). The last matchup of MVP-winning QBs that did not involve either Tom Brady or Peyton Manning came in Week 13, 2009, when Kurt Warner's Cardinals defeated Brett Favre's Vikings 30-17.

Dak Prescott won't be intimidated by the Broncos "No Fly Zone." While Denver had the NFL's #1 pass defense in 2016 (allowed 185.8 pass YPG), Prescott was 3-0 against Top 10 pass defenses in 2016, with 5 pass TDs, 0 INT, and a 122.2 passer rating in wins over the Ravens, Bears, and Vikings. The Broncos defense has been a nightmare for young QBs like Dak Prescott, who is 24 years old. Starting QBs in their 20s went 2-7 against the Broncos in 2016, with 2 pass TDs, 7 INT, and a 58.4 passer rating in those games.

Deshaun Watson will make his first NFL start on his 22nd birthday. Watson will be the 9th different starting QB for the Texans since 2014 (Bill O'Brien's first season), most of any team in the NFL.

Kareem Hunt's 246 scrimmage yards in Week 1 were the most by a player in his NFL debut since the 1970 merger. Hunt needs 200 scrimmage yards against the Eagles to break Billy Sims' record (since 1970) for scrimmage yards in a player's first 2 games (445).

Tom Brady and Drew Brees have combined for 128,251 career passing yards - most of any opposing QBs entering a game in NFL history. That's equivalent to nearly 73 miles of passing yards. Drew Brees is unfazed by Tom Brady and Bill Belichick. Brees is the only QB to make 4+ starts against Brady and have a winning record against TB12 (3-1). Brees is also the only QB with at least 100 pass attempts and a 100+ passer rating (123.1) against the Patriots in the Belichick era (since 2000).

The Giants have scored fewer than 20 points in seven straight games, including the playoffs. That is more than 3 times as long as the next-closest active streak (2 straight, 4 teams tied).

The Vikings/Steelers game features a matchup of 2 of the NFL's top rookies in Dalvin Cook and T.J. Watt. Cook's 127 rushing yards were 2nd-most of any player in Week 1, and Watt had 2.0 sacks and an INT in his debut - something his brother J.J. has never done in any of his 89 career games (including playoffs).

After losing in Green Bay in Week 1, the Seahawks should be happy to be headed home to host the 49ers in Week 2. In the Pete Carroll era (since 2010), the Seahawks are 12-0 at home and 2-10 on the road in September.

Less is more when it comes to Joe Flacco's pass attempts. Over the last five seasons, Flacco is 11-0 and has a 101.1 passer rating in games in which he throws 30-or-fewer passes. In games with more than 30 pass attempts, Flacco's passer rating is 79.6 and his record is 19-29 in that same span.

Leonard Fournette became the first rookie in Jaguars history to have 100+ rushing yards in his NFL debut, racking up 100 yards on 26 carries in Week 1 vs. Houston. Perhaps most impressive about Fournette's debut is that he faced 8+ defenders in the box on a league-high 57.7 percent of his carries.