The #1 overall pick in the 2018 NFL Draft, Baker Mayfield, will make his first start this week. Mayfield will be the 30th Browns quarterback to start a game since 1999. The previous 29 went a combined 2-26-1 in their first start with Cleveland.

During Week 3, Drew Brees passed Brett Favre for the most completions in NFL history. This week, Brees needs 418 passing yards to break Peyton Manning's NFL-record for career passing yards. Brees has 16 career 400-yard passing games, most of any QB in the Super Bowl era. Eight QBs have racked up 400+ passing yards in a game against the Giants in that span, most recently Brees in Week 8, 2015.

With 4.0 sacks, Khalil Mack has more sacks this season than the entire 53-man roster he left behind in Oakland who have a combined 3.0 sacks.

Patrick Mahomes has thrown 13 pass TD through three games this season, the most in the first three games of a season in NFL history.

With 473.3 yards per game, the Buccaneers have the league's #1 total offense. However, the Bears lead the NFL with 14 sacks this season. The last 10 times the league leader in sacks has matched up with the #1 total offense (including playoffs), the #1 total offense has won 9 times. The only time the sacks leader won was in Super Bowl XLII when the Giants beat the Patriots 17-14.

In his last four primetime games against the Ravens, Antonio Brown is averaging 122.3 receiving yards per game.

How good has Ryan Tannehill been for the Dolphins this season? Tannehill is 3-0, completing 73.0 percent of his passes, and has a 121.8 passer rating through the first three games. The only other QB in Dolphins history to start the first three games and post a passer rating of 120+ was Dan Marino in 1984. Marino went on to win NFL MVP and led the Dolphins to an appearance in Super Bowl XIX that season.

The Cowboys have hardly gotten anything out of their wide receivers. Cole Beasley leads Dallas with 132 receiving yards this season. Around the league, 13 different players have recorded 132 receiving yards in a single game through Week 3. Meanwhile, the Lions have 3 WRs (Golden Tate, Marvin Jones, Kenny Golladay) with more than 132 receiving yards this season.

In a game filled with stars on both sides of the ball, Kirk Cousins and Jared Goff take center stage. Cousins has more passing yards (965) than any quarterback in Vikings history through three games. Meanwhile, only Hall of Famer Kurt Warner ever had more passing yards than Jared Goff (941) among Rams quarterbacks at this point in a season.

The Chiefs are the second team to score more than 38 points in each of its first three games of a season since 1970, with the first being the 2007 Patriots.