Isaac Guerendo's 15-yard rushing score gives 49ers their first TD of 'SNF'

San Francisco 49ers rookie running back Isaac Guerendo's 15-yard rushing score gives the 49ers their first touchdown of their "Sunday Night Football" road game against the Buffalo Bills in Week 13 of the 2024 NFL regular season.

Watch all of Buffalo Bills quarterback Josh Allen's best plays from his 3-touchdown game on "Sunday Night Football" against the visiting San Francisco 49ers in Week 13 of the 2024 NFL regular season.

Watch all of Buffalo Bills running back James Cook's best plays from his 120-yard game in an AFC East-clinching win over the visiting San Francisco 49ers on "Sunday Night Football" during Week 13 of the 2024 NFL regular season.

Watch highlights from the Week 13 matchup between the San Francisco 49ers and the Buffalo Bills during the 2024 NFL season.

Buffalo Bills outside linebacker Greg Rousseau scoops up a fumble recovery as San Francisco 49ers quarterback Brock Purdy loses his grip on a slippery football.

Buffalo Bills wide receiver Jalen Virgil pounces on San Francisco 49ers wide receiver Deebo Samuel's fumble as the Bills' 'Sunday Night Football' avalanche continues.

Buffalo Bills tight end Dawson Knox follows up a contested 17-yard grab by making snow angels on the field.

Buffalo Bills quarterback Josh Allen becomes the second player in 19 years to rush, pass and receive a touchdown in the same game — making him the first player to do so since San Francisco 49ers running back Christian McCaffrey.

San Francisco 49ers wide receiver Deebo Samuel once again showcases his kick return prowess on a 42-yard return.

San Francisco 49ers wide receiver Jauan Jennings rewards the 49ers' fourth-down call with a 26-yard catch and run.

Buffalo Bills wide receiver Amari Cooper pitches to Bills quarterback Josh Allen for an improvised hook-and-ladder touchdown.

San Francisco 49ers wide receiver Deebo Samuel returns the half-opening kick 60 yards into Buffalo Bills territory.

Buffalo Bills safety Taylor Rapp forces San Francisco 49ers fullback Juszczyk into a goal-line fumble and costly 49ers turnover.

Buffalo Bills tight end Dawson Knox takes San Francisco 49ers safety Ji'Ayir Brown for a ride on a 39-yard catch and run.

Buffalo Bills wide receiver Mack Hollins' toe-tap touchdown catch vs. San Francisco 49ers cornerback Charvarius Ward boosts Buffalo Bills' lead to 20-3 over the visiting 49ers.

Buffalo Bills outside linebacker Greg Rousseau chases down San Francisco 49ers quarterback Brock Purdy to boosts his 2024 NFL regular season sack total to 6.5.

San Francisco 49ers running back Jordan Mason refuses to be tackled on a 27-yard burst.

Buffalo Bills running back James Cook goes dashing through the snow for a 65-yard touchdown.

Watch Jacksonville Jaguars wide receiver Parker Washington's Week 13 highlights against the Houston Texans.

Watch Houston Texans running back Joe Mixon's Week 13 highlights as he rushed for 101 yards and added 18 more yards in the air against the Jacksonville Jaguars.

Buffalo Bills running back Ray Davis dives past the pylon for a touchdown on 'Sunday Night Football' to send Bills fans into a snowball-throwing frenzy in their Week 13 matchup against the visiting San Francisco 49ers.

San Francisco 49ers cornerback Renardo Green breaks up Buffalo Bills quarterback Josh Allen's improvised loft to Bills wide receiver Khalil Shakir.

Watch Carolina Panthers wide receiver Adam Thielen's Week 13 highlights against the Tampa Bay Buccaneers.

San Francisco 49ers kicker Jake Moody's 33-yard field goal helps 49ers strike first on 'Sunday Night Football' against the Buffalo Bills.

Watch Tampa Bay Buccaneers wide receiver Mike Evans's Week 13 highlights as he caught eight passes for 118 yards against the Carolina Panthers.