O'Brien's challenge for defensive PI on fourth down is unsuccessful

Best plays from Philadelphia Eagles running back Saquon Barkley's 198-yard, two-touchdown game against the Washington Commanders from Week 11 of the 2024 NFL season.

Best plays from the Miami Dolphins defense vs. the Los Angeles Rams during Week 10 of the 2024 NFL season.

Watch all of Detroit Lions running back Jahmyr Gibbs' best plays from his 108-yard game against the Houston Texans on "Sunday Night Football" in Week 10 of the 2024 NFL regular season.

Watch Philadelphia Eagles quarterback Jalen Hurts' Week 10 highlights as he combined for four total touchdowns with 202 passing yards and 56 rushing yards against the Dallas Cowboys.

Watch Philadelphia Eagles wide receiver A.J. Brown's Week 10 highlights as he caught five passes for 109 yards against the Dallas Cowboys.

Watch Arizona Cardinals running back James Conner's Week 10 highlights as he combined for 113 yards against the New York Jets.

Arizona Cardinals quarterback Kyler Murray was 22-for-24, including a franchise record 17 consecutive completions, in his team's Week 10 win against the New York Jets.

Watch every catch from Tennessee Titans wide receiver Calvin Ridley's 2-touchdown game against the Los Angeles Chargers in Week 10 of the 2024 NFL regular season.

Watch San Francisco 49ers quarterback Brock Purdy's Week 10 highlights as he passed for 353 yards in a 23-23 win over the Tampa Bay Buccaneers.

Watch the best throws from Denver Broncos quarterback Bo Nix from his 215-yard, 2-TD game during Week 10 of the 2024 NFL season.

Watch the best plays from New Orleans Saints quarterback Derek Carr's 2-touchdown game vs. the Atlanta Falcons during week 10 of the 2024 NFL season.

Watch the best plays from Atlanta Falcons running back Bijan Robinson's 2-touchdown game vs. the New Orleans Saints during Week 10 of the 2024 NFL season.

Watch the New England Patriots' best plays on defense against the Chicago Bears as they sacked quarterback Caleb Williams nine times.

Watch Washington Commanders wide receiver Terry McLaurin's Week 10 highlights against the Pittsburgh Steelers as he caught five passes for 113 yards.

Watch the best throws from Pittsburgh Steelers quarterback Russell Wilson from his 3-TD game during Week 10 of the 2024 NFL season.

Indianapolis Colts running back Jonathan Taylor's best plays from his 122-yard game vs. the Buffalo Bills from Week 10 of the 2024 NFL season.

Watch San Francisco 49ers running back Christian McCaffrey's best plays from first game of 2024 season during Week 10 vs. Tampa Bay Buccaneers.

Watch Carolina Panthers running back Chuba Hubbard's best plays from 169-yard game in Germany from Week 10 of the 2024 NFL season.

Watch all 11 catches from Cincinnati Bengals wide receiver Ja'Marr Chase's 264-yard, 3-touchdown game against the Baltimore Ravens in Week 10 of the 2024 NFL regular season.

Watch all of Cincinnati Bengals quarterback Joe Burrow's best throws from his 428-yard, 4-TD game against the Baltimore Ravens on "Thursday Night Football" in Week 10 of the 2024 NFL regular season.

Watch all of Baltimore Ravens quarterback Lamar Jackson's best plays from his 323-yard, 4-touchdown game against the Cincinnati Bengals on "Thursday Night Football" in Week 10 of the 2024 NFL regular season.

Kansas City Chiefs quarterback Patrick Mahomes' best plays in his three touchdown game against the Tampa Bay Buccaneers from Week 9 of the 2024 NFL season.

Kansas City Chiefs running back Kareem Hunt's best plays in his 106-yard game against the Tampa Bay Buccaneers from Week 9 of the 2024 NFL season.

Kansas City Chiefs tight end Travis Kelce's best plays in his career-high 14-catch game against the Tampa Bay Buccaneers from Week 9 of the 2024 NFL season.

Kansas City Chiefs wide receiver DeAndre Hopkins' best plays in his two touchdown game against the Tampa Bay Buccaneers from Week 9 of the 2024 NFL season.