Prime makes his Seahawks-Rams pick for Week 10

NFL Network's Deion Sanders and Maurice Jones-Drew debate which quarterback matchup they want to see in the Super Bowl.

NFL Network's Deion Sanders and Maurice Jones-Drew debate which sports dynasty is better between the 1990s Chicago Bulls and the New England Patriots under head coach Bill Belichick.

NFL Network's Deion Sanders explores whether defense still wins championships, as the remaining four teams in the playoffs were the four highest-scoring teams in the regular season.

NFL Network's Maurice Jones-Drew joins "21st and Prime" to debate with the crew on which team will have a bigger impact in the NFL Championship game.

NFL Network's Deion Sanders ranks the remaining quarterbacks playing in the playoffs in the championship round.

NFL Network's Deion Sanders discusses the trade rumors surrounding Pittsburgh Steelers wide receiver Antonio Brown.

NFL Network's Deion Sanders explains why University of Oklahoma Sooners QB Kyler Murray should play baseball instead of going to the NFL.

NFL Network's Deion Sanders shares what he is most excited for on Championship Sunday.

NFL Network's Deion Sanders "Prime" reveals his picks for the Divisional Round.

NFL Network's Maurice Jones-Drew and Deion Sanders debate which road team has the best chance to win in the Divisional Round this weekend.

NFL Network's Deion Sanders and NBC Sports' Peter King discuss why King left Pittsburgh Steelers wide receiver Antonio Brown off his All-Pro ballot.

NFL Network's Mike Garafolo and Deion Sanders discuss the Green Bay Packers' hiring of Matt LaFleur as their next head coach.

NFL Network's Mike Garafolo and Deion Sanders discuss the Tampa Bay Buccaneers' hiring of Bruce Arians as their next head coach.

NFL Network's Mike Garafolo breaks down the bonuses Philadelphia Eagles quarterback Nick Foles can earn with each postseason win.

NFL Network's Deion Sanders makes his picks for Wild Card Weekend.

NFL Network's Mike Garafolo and Deion Sanders discuss Jacksonville Jaguars running back Leonard Fournette and his future with the Jaguars.

NFL Network's Maurice Jones-Drew and Deion Sanders discuss which teams playing on Wild Card Weekend they believe can make a run.

NFL Network's Maurice Jones-Drew and Deion Sanders discuss which first-year head coach has been the most impressive.

NFL Network's Deion Sanders tries to come up with a New Year's resolution and solution for Minnesota Vikings quarterback Kirk Cousins' current situation.

NFL Network's Deion Sanders tries to come up with a New Year's resolution and solution for Pittsburgh Steelers wide receiver Antonio Brown's current situation.

NFL Network's Mike Garafolo and Deion Sanders discuss Philadelphia Eagles quarterback Nick Foles future with the Eagles.

NFL Network's Mike Garafolo and Deion Sanders discuss the trade rumors surrounding Pittsburgh Steelers wide receiver Antonio Brown.

NFL Network's Maurice Jones-Drew and Deion Sanders discuss who will be holding the Lombardi Trophy in Atlanta this season, a first-time winner or previous champion?

NFL Network's Mike Garafolo and Deion Sanders discuss Carolina Panthers head coach Ron Rivera's job security after his team's sixth-straight loss.

NFL Network's Deion Sanders explains why he's not worried about the Seattle Seahawks' Week 15 loss to the San Francisco 49ers.