- WHERE: Lumen Field
- WHEN: 8:15 p.m. ET | Prime Video, NFL+
49ERS
- QB Jimmy Garoppolo
- WR Deebo Samuel
- OL Nick Zakelj
- DL Kevin Givens
- LB Curtis Robinson
- CB Samuel Womack III
- DB Tarvarius Moore
SEAHAWKS
- RB DeeJay Dallas
- RB Tony Jones Jr.
- OT Jake Curhan
- DT Al Woods
- CB Tre Brown
- CB Artie Burns